This presentation describes a label-free, photonics-based sensor system being developed to detect chemicals/metabolites in body fluids for medical diagnosis and intravenous (IV) drug monitoring. Modalities demonstrated are surface-enhanced Raman scattering (SERS) for specific chemical identification and localized surface plasmon resonance (LSPR) for capture affinity biosensing, with both techniques configured for continuous analyses on fluid samples (Figure 1a). Simultaneous, high-performance SERS and LSPR measurements for a wide range of target analytes (drug compounds, metabolites, proteins) are enabled by incorporating plasmonic nanodome array structures (Figure 1b) into sample delivery tubing. These metallic nanostructures, which produce large electric field enhancement (Figure 1c), are fabricated using a high-fidelity, nanoreplica molding method. To investigate potential applications in medical diagnostics and drug monitoring, SERS measurements on an IV-delivered pain medication (promethazine) and a common metabolite (urea) have been performed at physiologically relevant concentrations. Results from these studies are shown in Figure 2.

Plasmonic nanodome array for point-of-care medical diagnostics

244th National Meeting (2012)

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