Small molecules such as carbohydrates, lipids, metabolites and drugs play essential roles in the biochemistry of living cells. However, monitoring the spatiotemporal dynamics of these small molecules represents a formidable challenge. Label-free microscopy using spectroscopic signals as contrast opens a new window for watching molecules and nanomaterials inside living cells and organisms. I will present our most recent advances in both development and applications of label-free imaging platforms, including deep tissue imaging by listening to harmonic molecular vibration, study of lipid metabolism in human cancer, and transient absorption imaging of carbon nanotubes.

Seeing the secret in life through label-free spectroscopic imaging

244th National Meeting (2012)

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