A facile method to prepare stimuli-responsive nanogels as therapeutic delivery vehicles based on activated polyesters and diamino cross-linkers has been developed. Cross-linking reaction was characterized by NMR and FTIR. Nanogels synthesized can easily encapsulate lipophilic guest molecules and are water-dispersible, size tunable and surface-functionalizable. pH responsive and enzyme substrate functionalities have been incorporated into nanogels for delivering therapeutic molecules.  The in vitro and in vivo study and drug release characteristics will be discussed.

Surface-decorated polymer nanogels from activated polyesters for biological application

244th National Meeting (2012)

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