Glycosylphosphatidylinositol (GPI) glycolipids anchor a large number of proteins in the cell membrane of eukaryotic cells. Their conserved pseudopentasaccharide core (H2N(CH2)2OPO3H6Mana1?2Mana1?6Mana1?4 GlcNa1?6myo-Ino1-OPO3H�) can carry additional phosphoethanolamine, saccharide and lipid substituents. Biological studies of  GPIs rely on availability of homogeneous samples of these molecules. To address the need for a diverse set of homogeneous GPI structures we have developed a general synthetic route to GPI molecules. Here, we report on the development of this synthetic strategy, and the application of different branched GPI glycans and glycolipids as diagnostic tools and potential vaccines.

General and convergent route for synthesis of diverse glycosylphosphatidylinositols: Applications in diagnostics and vaccines

244th National Meeting (2012)

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