Comprehensive two-dimensional liquid chromatography (LC�LC) is a powerful separation tool for non-volatile samples. High peak capacities may be obtained in a reasonable time. The efficiency of LC�LC separations can be enhanced in very much the same way as in one-dimensional LC.However, it is evident from the oeuvre of Wolfgang Lindner that successful separations in LC are achieved more often through selectivity than through efficiency. More problems have been solved by smart ideas than by brute force.The role of selectivity is even greater in LC�LC than in one-dimensional LC. If the two dimensions show the same selectivity it is pointless to use LC�LC. Conversely, the greater the difference in selectivity (i.e. the �more orthogonal� the phase systems) the greater and the clearer are information obtained from LC�LC experiments.In this lecture the role of selectivity in LC�LC is discussed in relation to the properties (�dimensions�) of the sample.

Selective 2D liquid-chromatographic separations

244th National Meeting (2012)

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