Widespread resistance is a serious public health challenge that limits the use of high efficacy insecticides to reduce the risk of mosquito-vectored diseases. P-glycoprotein (P-gp) is a multi-specific drug efflux transporter that assists in maintaining the blood-brain barrier interface of mosquitoes and, in turn, can limit the target-site action of insecticidal chemistries for their control. In this presentation, we will show the: 1) molecular analysis of P-gp subfamilies that confer the multi-drug resistant phenotype; 2) toxicological modification of established and experimental insecticides alone and in combination with P-gp inhibitors; and 3) P-gp-mediated transport and target-site action of these insecticides in vector mosquitoes.

Mosquito P-glycoproteins and their emerging role in insecticide resistance

244th National Meeting (2012)

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