Before collagen can be properly folded and assembled, a serious of posttranslational modifications on the central (Gly-Xxx-Yyy)n domain must occur, including hydroxylation of most Pro and some Lys residues in the Yyy position followed by glycosylation of 5-hydroxylysine  residues. The main aim of this work is to determine the effect of hydroxylation / glycosylation of Lys residues on receptor binding to type IV collagen. Synthesis of glycosylated hydroxylysine that can be incorporated into collagen-like peptides would be greatly aided by convenient preparation of glycosylated hydroxylysine building blocks. Results on comparison of various synthetic methods and optimal synthetic routes for the production of glycosylated hydroxylysine will be presented.

Synthesis and use of glycosylated hydroxylysine

244th National Meeting (2012)

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