Glycosaminoglycans are a family of polysaccharides widely distributed at the surfaces of all eukaryotic cells. These polyanionic, linear chain polysaccharides are composed of repeating disaccharide units that are often differentially substituted with sulfo groups.  The diversity of glycosaminoglycan structures in cells, tissues and among different organisms reflect their functional an evolutionary importance.  Glycosaminoglycan composition and structure also changes in development, aging and in disease progression, making their accurate and reliable analysis a critical, albeit, challenging endeavor.   Quantitative disaccharide compositional analysis is one of the primary ways to characterize glycosaminoglycan composition and structure and has a direct relationship with glycosaminoglycan biological functions. In this work, several highly sensitive and fast methods were reported and applied to analysis of GAGs-derived from various biological tissues and cells samples.

Disaccharide compositional analysis of glycosaminoglycans from biological tissues and cells

244th National Meeting (2012)

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