Glycobiology/glycomics research is currently undergoing rapid development as a result of recent advances in technologies for glycan structural analysis that is beginning to unravel the structure-activity relationships of glycan-protein interactions.    Surface plasmon resonance (SPR) is a powerful biosensor technique used to measure biomolecular interactions in real-time in a label-free environment. Our research glycobiology/glycomics is focused on glycosaminoglycans (GAGs), which are a family of highly sulfated, complex, polydisperse linear polysaccharides that display a variety of important biological roles.  SPR spectroscopy has been successfully used for quantitative modeling of GAG-protein, and biological evaluation of glycotherapeutics (such as heparin and low molecular weight heparins) in our lab.  This presentation reports SPR interaction studies on the interactions between GAGs and proteins and the application of SPR in glycomics study on GAGs from biological samples.

Glycobiology/glycomics research using SPR biosensors

244th National Meeting (2012)

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