We are interested in exploration of virus like particles (VLPs) as versatile platforms for the development of carbohydrate based cancer vaccine. The highly repetitive array of subunit in VLPs permits the organized display of antigens on the surface of the particle. The VLPs also contain natural T-helper epitopes and pathogen associated molecular patterns, which can engage innate immunity and activate the immune system. Herein, we present the vaccination studies with Tn antigen conjugated to several different types of VLPs. Although all particles have accessible moieties for conjugation, these attachment points differ in number, geometrical arrangement, and conformational flexibility. The display pattern on VLPs was found to have great influence on the outcome of immune responses. The role of other parameters such as linker, adjuvant, and antigen density in the generation of strong and specific immune response will also be discussed.

Virus-like particles (VLPs) as promising platform for cancer vaccine

244th National Meeting (2012)

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