Quinone reductase 2 (QR2) has been identified as an enzyme that plays a role in the reduction of reactive quinone molecules. Unlike QR1, which contributes toward the detoxification of quinones and protection of cells, QR2 activity has been linked to increased cellular damage due to the production of more reactive compounds. This suggests that the inhibition of QR2 may be beneficial for cell protection. Resveratrol, a polyphenol found in certain kinds of grapes, has been shown to be a potent competitive inhibitor of QR2, potentially explaining its observed antioxidant effects.  We have therefore synthesized novel reseveratrol analogs and examined their potency for QR2. Enzyme inhibitory constants (Ki) were measured via an absorbance assay using N-methyldihydronicotinamide as an electron-donor to prime QR2 and menadione as a substrate.

Inhibition of quinone reductase 2 by novel resveratrol analogs

244th National Meeting (2012)

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