Dopamine (DA) is a very important chemical in the brain when it comes to the functionality of cognition.  A low concentration of dopamine in the synapses can lead to slow, weakened signals sent from the brain to the rest of the body.  The levels of DA in the brain are regulated by dopamine transporters (DATs), which remove dopamine from the synapse.  Dopamine transport inhibitors can be used to block the reuptake of dopamine into the neurons, causing an increased concentration of dopamine in the synapse.  This increased concentration can lead to stronger, faster brain messages sent throughout the rest of the body.  Based on the structure-activity relationships of two known DAT inhibitors, bupropion and methylphenidate, a novel DAT inhibitor structure was designed and a short synthesis from known intermediate species was attempted.

Toward the synthesis of a novel dopamine transport inhibitor

244th National Meeting (2012)

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