Ornithine decarboxylase (ODC) is the first and rate limiting step of the polyamine biosynthetic pathway. ODC catalyzes ornithine to produce putrescine, which is the precursor of polyamines such as spermidine, and spermine . These polyamines are necessary for cell growth and proliferation. Studies have shown that tumor cells have higher concentrations of these polyamines than other cells. ODC has become an ideal target for tumor treatment due to regulationg  polyamine concentrations in abnormal cells.  Here we present the microwave-assisted synthesis of (S)-2-amino-5-(hydroxyamino)-5-oxopentanoic acid (AHOPA) as a potential inhibitor of ODC. Biological activity  will be under investigate in the future work in collaborative works with other institutes.

Design and synthesis of inhibitors of ornithine decarboxylase using hydroxamate functionality in the polyamine biosynthetic pathway

244th National Meeting (2012)

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