Inflammatory bowel diseases (IBD) are a series of circumstance which lead to the inflammation of the colon and small intestine. IBD begin when the body initiates an abnormal immune response to normal bacteria flora. In many cases of IBD, a link has established that chemokines as one of the key factors regulating IBD pathogenesis. Chemokines are a family of small cytokines that facilitate the migration of circulating leukocytes to the inflamed site.  Chemokines such as, monocyte chemotactic protein 1, macrophage protein 1-a, MIP-1b, RANTES, and interferon inducible protein 9 and 10 are reported to express in larger quantities during the active phase of the disease. Many of these chemokines are produced by immune cells.  However, little is known about the role of colonic epithelial cells in immune cell recruitment.  We evaluated these chemokine productions from isolated colonic epithelial cells using real time PCR in mouse model of inflammatory bowel diseases.

Chemokine production in inflammatory bowel diseases

244th National Meeting (2012)

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