A current goal for researchers in the field of bionanotechnology is the development of a nanotransport system that uses biomolecular motors for controlled cargo manipulation and could be used for the sorting, purification, and assembly of materials on a molecular scale.  Our group has developed an actin bundle-myosin motor system for use within a hybrid PDMS/glass microfluidic device.   In this system, ATP fuels the movement of the actin bundles along the myosin-coated device floor within the channel to ensure the directional movement of the bundles.  To further enhance the development of a nanotransport system, we use the microfluidic device to start and stop the filaments, which will be needed for cargo manipulation.  Along the channel we have implemented orthogonal intersections designed to start and stop the bundles by using laminar flow of ATP and ATP-free solutions.

Development of a method to manipulate movement of actin bundles within a hybrid microfluidic device

244th National Meeting (2012)

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