The understanding and control of polymorphic form and crystal size is important in materials science. In this study, we outline various micro- and macro-scale approaches to control of crystallization of the model compound, glycine. We have applied the following three methods to generate various glycine polymorphs: an isothermal microdroplet crystallization method; a hanging drop method; and an emulsion crystallization method. Crystal form was characterized by microscopic image analysis and by ATR-IR spectroscopic technique. It was found that for these methods, rate of evaporation, surfactant type, and additive type appears to contribute to the observed polymorphic form.

Generation and analyis of glycine polymorphs: Micro and macro approaches

244th National Meeting (2012)

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