The interactions of several proteins such as bovine serum albumin (BSA), human serum albumin (HSA) and hemoglobin with nanoparticles (metal oxides) was monitored by various spectroscopic techniques (i.e., absorbance, fluorescence, infra-red). Serum albumins were selected and used because both served as a model protein in many and diverse biophysical, biochemical and physicochemical studies due to its role in the transport and deposition of a variety substance in blood. Results showed the preferential binding of some nanomaterials with the proteins. This study will report on the binding of the nanomaterials with the three proteins and the effect of different parameters (pH and ionic strength) on the binding interactions.

Binding of different proteins with different nanoparticles monitored by spectroscopy

244th National Meeting (2012)

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