Evident by the ubiquitous nature of heterocycles in biological systems, these building blocks, through their rigidity and either hydrophobic or hydrophilic interactions, play key roles in drug development. As a consequence, new synthetic sequences for their construction are essential. This study highlights the facile, solvent-free coupling of various diallylamines with methyl thioglycolate to generate an assortment of thiomorpholin-3-ones.

Thiomorpholin-3-ones via a solvent-free tandem amidation/cyclization

244th National Meeting (2012)

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