Substituted benzylformamides are important intermediates in the synthesis of numerous biologically active compounds, including agrochemicals and pharmaceuticals.  Recently, we developed an accelerated procedure for the synthesis of formamides.  It was important to investigate if the procedure can be successfully applied for the synthesis of benzylformamides with electron-withdrawing substituents, for example N-(2,4-dichlorobenzyl)formamide.  Column chromatography was used for the isolation of the products of the reaction.  NMR, MS and elemental analysis were used to determine the structure of the products.   The reaction was completed in 1 minute and produced N-(2,4-dichlorobenzyl)-formamide in good yield.  Three byproducts were isolated and their structures were determined.  The new reaction opens the way for the fast synthesis of N-(2,4-dichlorobenzyl)amine and its derivatives.  The project is supported by NIH grant P20 RR016741 from the NCRR and by the Great Plains Center for Community Research and Service as funded by the US Department of Education Grant Award P1 16Z100151

Rapid synthesis of N-(2,4-dichlorobenzyl)formamide

244th National Meeting (2012)

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