Robust methods for the chemical synthesis of high molecular weight polysaccharides is an unmet challenge for polymer chemists. Introducing an amide linkage between sugar repeat units instead of an ether linkage is a strategy that could allow the molecular-level control available via organic synthesis while maintaining some of the unique properties of natural polysaccharides. In response to this need, the synthesis and characterization of chiral, controlled molecular weight poly-amido-saccharides via the anionic ring-opening polymerization of a �-lactam sugar monomer will be presented. The characterization of poly-amido-saccharides using NMR, IR, DLS, CD, and microscopy will be discussed and related to the molecular structure of the polymers. Finally, bioactivity studies and potential biomaterials applications of poly-amido-saccharides will be addressed.

Poly-amido-saccharides: New carbohydrate-based biomaterials

244th National Meeting (2012)

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