The ability to arrest the cell growth of two pancreatic cancer cell lines was studied for organotin polyesters derived from chelidonic acid and thiodiglycolic acid. For the chelidonic acid polymers, in general, with the exception of dibutyltin dichloride, the polymers exhibit lower GI50 values compared to the monomers.  For thiodiglycoloic acid-derived polymers, again, in general, the polymers show better inhibition of the cancer cell lines compared to cisplatin. The CI50 values for the polymers are mostly less than 1 with no values greater than two.

Inhibition of pancreatic cancer cell lines by organotin polyesters containing thiodiglycolic acid and chelidonic acid

244th National Meeting (2012)

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