Rapid diffusion of the physically encapsulated drug from polymeric nanoparticles during circulation in bloodstream and slow intracellular release are the major bottle necks of nano-therapeutics based drug delivery. In this study, we designed a redox-sensitive polymer-drug conjugate system and formulate a micelle type nano-therapeutics with targeting moieties. The anti-cancer activity of the nanoparticle was investigated in human colon cancer cell line, HCT-116. The ideal polymer poly(PDA) was synthesized by free radical polymerization of pyridyl disulfide acrylate (PDA) followed by conjugation of PEG (Mw 5.0 Kda) and camptothecin (CPT). The nanoparticles showed redox-potential tunable In vitro drug release profiles. The conjugation of herceptin (HER) significantly improved the anticancer activity of the nanoparticles (day-2 and 3) in HCT-116 cell. These results suggest that poly(CPT-g-PDA-g-PEG) with HER moieties could be a promising nano-therapeutics for tumor-targeted drug delivery.

Camptothecin conjugated redox-sensitive nanoparticle for targeted drug delivery

244th National Meeting (2012)

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