Ginsenosides are a family of triterpene saponins that are thought to be the primary compounds responsible for the reported health benefits gained from consuming ginseng as a dietary supplement.  Ginsenosides prevalent in both Panax ginseng (Asian ginseng) and Panax quinquefolius (American ginseng) include ginsenosides Rb1, Rb2, Rc, Rd, Re, and Rg1.  NIST is currently developing standard reference materials containing ginsenosides and ginseng-derived materials.  This work discusses the development of method using liquid chromatography coupled with ultraviolet absorbance detection and mass spectrometry for the determination of ginsenosides in solution.  The LC-UV-MS method is used to certify the amount of ginsenosides Rb1, Rb2, Rc, Rd, Re, and Rg1 present in a calibration solution standard reference material.

Development of a LC-UV-MS method for the determination of ginsenosides in a standard reference material

244th National Meeting (2012)

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