Hexabromocyclododecane (HBCD) is a persistent flame retardant manufactured as a mixture of a-, �-, and ?-stereoisomers.  ?-HBCD dominates the commercial product, while a-HBCD dominates biotic residues.  Differential metabolism of a- and ?-HBCD is thought to influence a-HBCD bioaccumulation, but the contribution of �-HBCD is unknown.  The goal of this research was to measure the fate of radiolabeled HBCD stereoisomers in rats.  Each isomer was eliminated in feces and urine, with elimination of � > ? > a.  Oxidation, stereoisomerization, and conjugation were evident.  Adipose tissue, GI tract, skin, and liver contained the greatest concentration of residues, and bound residues were significant in liver and feces.  a-HBCD exceeded the concentrations of the �- and ?-HBCD in brain by 5-20 times.   Persistence of HBCD stereoisomers was generally low and was isomer specific.  Differences in isomer fate were due to metabolism and isomerization, and are consistent with the observed stereoisomer profiles in biota.

Comparative metabolism of [<i><sup>14</sup>C</i>]α-, β-, and γ-hexabromocyclododecane (HBCD) in rats

244th National Meeting (2012)

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Comparative metabolism of [14C]α-, β-, and γ-hexabromocyclododecane (HBCD) in rats

Comparative metabolism of [¹⁴C]α-, β-, and γ-hexabromocyclododecane (HBCD) in rats