Vitamin D is a steroid molecule formed by the body after exposure to UV radiation or obtained in the diet through fatty animal products, fortified foods, or supplements.  In recent years, it has been reported that having a sufficient amount of vitamin D circulating in the body correlates with reduced chance of developing many diseases of modern life, and managing these diseases better if they do develop.  Among the conditions reported to be prevented or improved in the presence of sufficient vitamin D are cancer, including breast, colon, and prostate, diabetes, heart disease, inflammatory bowel disease, and various autoimmune diseases.  The mechanism by which sufficient levels of the vitamin D precursor 25-(OH)-D3, and the active form 1,25-(OH)2-D3, modulate the immune system and lowers risk of these diseases is not completely clear.  It is also unclear whether cells will make their own activated vitamin D from the precursor molecule.   This poster will explore the modulation of expression of vitamin D metabolizing enzymes by both 25-(OH)-D3 and 1,25-(OH)2-D3 in various breast cancer cell lines in order to probe this mechanism.

Examination of vitamin D metabolizing enzymes in breast cancer cells

244th National Meeting (2012)

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