Catalysts based on the CH activation/M-R functionalizations reaction have the potential to facilitate facile, selective conversion of unactivated CH bonds.  Several catalysts systems have been developed that operate by integration of these reactions.  However, to date, none are practical largely due to the requirement for strongly acidic media that lead to expensive separations and substrate scope.  To address this we are exploring the design of new classes of CH activation and M-R functionalization reactions that do not require strongly acidic media.  Key considerations to the integration of these new reactions into effective catalysts are, in addition to high reaction rates, ensuring reaction compatibility, minimizing reaction of the desired product and stabilizing the catalyst.  We will discuss these new reactions, the challenges encountered in designing effective catalysts and how the knowledge obtained in the study could provide some guidance to new designs.

Designing catalysts for CH functionalization based on the CH activation reaction

244th National Meeting (2012)

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