While the mechanism of hydrogen transfer through the human proton channel is the subject of muchdebate, the actual structure of the ion channel has not been completely clarified except throughhomology with the Shaker channels and with the voltage sensing domains of other ion channels.Hence the actual mechanism of transfer cannot be determined with certainty. In this work we willpresent a structure for the proton channel based upon a homology model from the Shaker channelfurther refined with new experimental data from the labs of Peter Lars.

Elucidating the structure of hydrogen ion channel of <i>Ciona intestinalis</i>

244th National Meeting (2012)

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Elucidating the structure of hydrogen ion channel of Ciona intestinalis