Gas/liquid phase heterogeneous catalytic reactions with simple added gas components are very efficient processes in the pharmaceutical, agro and fine chemical industry.  Employing traceless gaseous reagents over chemicals allows to develop greener processes reducing the waste and the purification burden.  While hydrogenation is extensively used in continuous flow processes due to safe in situ generation in a flow reactor oxidation with molecular oxygen or (hydro)formylation with CO are not fully exploited due to the strict technological requirements for safe operation.  In a recent edition of a fixed-bed continuous flow reactor various external gas components can be applied including O2, CO or CO2.  We report various oxidation reactions using catalyst-packed reactor cartridges and elementary oxygen (including aromatization, convertion of primer and secunder alcohols to aldehydes vs. ketons, epoxidation, Baeyer-Villiger oxidation, oxidation of sulfides to sulfoxide or sulfone) and (hydro)formylation with (H2/CO) which demonstrate the various opportunities in continuous flow.

Heterogenous catalytic oxidation and formylation reactions in a gas/liquid continuous flow reactor

244th National Meeting (2012)

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