The validation of a gas chromatography (GC) method developed to quantify amounts of starting material from the synthesis of hyperbranched polymers made from glycerol and either succinic acid, glutaric acid, or azelaic acid is described.  The GC response to concentration was linear for all starting reagents (R2 > 0.996).  The data could be reproduced, on average, with 93.05% confidence for analyte concentrations of 0.5% and with greater than 98% confidence for analyte concentrations of 1.0 and 5.0%.  GC data generated from recovery studies that involved the addition of 1.0 mg (5 wt %), 0.2 mg (1.0 wt %), or 0.1 mg ( 0.5 wt%) of each starting material to the polymer samples gave near perfect correlations between expected and detected amounts of starting materials in polymers made from glycerol and succinic acid or glutaric acid.  The correlation between expected and detected amounts of analyte decreased for the azelaic acid analogues as the amounts of added starting material was decreased.  However, in our worst case, this decrease represents 0.31% of the total mass of the diacid analyzed.

Quantification of unreacted monomers in poly(glycerol-<i>co</i>-diacid) gels using gas chromatography

244th National Meeting (2012)

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Quantification of unreacted monomers in poly(glycerol-co-diacid) gels using gas chromatography