Local delivery strategies can be achieved either by injecting the therapeutic at the desired site or using a targeted strategy.  For the former, we have designed an injectable hydrogel that allows local delivery to the central nervous system.  By injecting the hydrogel in which biomolecules are dispersed onto the brain, we are able to circumvent the blood-brain barrier and achieve local release of the biomolecules directly to the brain tissue.  By incorporating polymeric particles into this design, we are able to meter the release profile.  For the latter, we have designed polymeric particles with targeting antibodies on their surface that achieve local delivery to cancer tissue after intra venous (i.v.) injection.  By taking advantage of the hyperpermeable vasculature in a cancer tissue, polymeric nanoparticles will selectively accumulate in the cancer tissue and deliver encapsulated chemotherapeutic therein.

Local delivery strategies

244th National Meeting (2012)

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