64Cu-complexed tetraamines have shown great promise as cancer imaging agents using positron emission tomography (PET). Previous work in our group has shown that phosphonate-armed cross-bridged cyclam, CB-TE1A1P 1  , binds 64Cu under milder conditions than the carboxylate-armed ligand, CB-TE2A 2  .1 Herein we report the synthesis of novel cross-bridged tetraamines pendant phosphonate groups (3  �5  ) and exploration of their copper chemisty. Ref:1.  Dannon J. Stigers, Riccardo Ferdani, Gary R. Weisman, Edward H. Wong, Carolyn J. Anderson, James A. Golen, Curtis Moore and Arnold L. Rheingold,  Dalton Trans., 2010, 39  , 1699.

Synthesis of new phosphonate-armed cross-bridged tetraamines for radiopharmaceutical applications

244th National Meeting (2012)

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