Oxidative heterocoupling, the ability to simultaneously cleave two nonequivalent C-H bonds and form a new C-C  bond, is a rare, but very important chemical transformation because it  alleviates the need to prefunctionalize substrates prior to the coupling  reaction.  This presentation will discuss the development of general  conditions that can be used for oxidative heterocouplings of both  electron-rich and electron-poor arenes, the mechanisms of these reactions, and the development of new oxidative coupling transformations, such as the synthesis of aniline derivatives via oxidative amination.

Synthesis of C-C and C-N bonds via oxidative C-H functionalization

244th National Meeting (2012)

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