A nickel-catalyzed cross-coupling reaction between N-sulfonyl aziridines and organozinc reagents will be described. The catalytic system comprises an inexpensive and air-stable Ni(II) source and dimethyl fumarate as ligand. Regioselective synthesis of �-substituted amines is possible under mild and functional group-tolerant conditions. The stereoselectivity of the reaction is consistent with a stereoconvergent mechanism wherein the sulfonamide directs C-C bond formation.

Nickel-catalyzed Negishi alkylations of styrenyl aziridines

244th National Meeting (2012)

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