Despite extensive efforts in recent years to improve the scope of metal-catalyzed alkyl�alkyl cross-couplings reactions,1 a number of challenges still remain unsolved. For instance, the use of acyclic secondary alkyl nucleophiles often results in isomerization to the n-alkylated product.In this contribution, we present the development of nickel catalysts for cross-coupling acyclic secondary nucleophiles with benzylic halides.

Nickel catalysts for cross-couplings of acyclic secondary nucleophiles with benzylic halides

244th National Meeting (2012)

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