The brain requires among the highest levels of metals in the body for normal function, including redox-active copper and iron, but misregulation of these metals is connected to aggregation and oxidative stress cascades that occur with aging and age-related neurodegenerative diseases. We have initiated a broad-based program to study the complex roles of metal ions and redox biology in brain health, aging, and disease by creating new fluorescent and MRI indicators to track metal ions and oxygen and sulfur metabolites in living cells, tissue, and organisms. The design, synthesis, and evaluation of our most recent platforms and their use in molecular imaging will be presented.

Molecular imaging approaches to studying inorganic chemistry in the brain

244th National Meeting (2012)

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