We report on controlled polymerization techniques of poly(glycidol) in which the branching can be controlled, ranging from purley linear poly(glycidols) to systems with 10-25% branching. Polyglycidols with controllable degrees of branching can be investigated as valuable alternatives to polyethylene glycol in bioconjugate materials or as part of nanoparticle structures. Moreover, we have developed novel glycidol monomers with cleavable units to afford degradable materials for drug delivery. In several experiments we have optimized the incorporation of these monomers to create completely novel poly(gycidols). We will also report on copolymers of valerolactone and glycidol as part of supramolecular nanosponge materials, prepared via an intermolecular chain crosslinking procedure.

Synthesis of polyglycidols with linear and controlled branched structures: Study of the reaction kinetics and postmodification into nanosponges as drug delivery systems

244th National Meeting (2012)

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