MannKind's Technosphere� technology provides a simple, patient friendly method to administer drugs to the lung for local or systemic delivery.  The technology consists of 1) dry powder formulations prepared with FDKP, a novel excipient, and 2) an innovative breath-powered inhaler that is �tuned� to the properties of the Technosphere powder.  The particles have a median size of about 2 �m and are ideal for pulmonary delivery.  Particles formed by crystallizing the dicarboxylic acid form of FDKP can be �loaded� with a wide variety of APIs by adsorbing the drug onto the particles and then removing solvent. After inhalation, the FDKP dissolves quickly at physiologic pH and releases the drug.  The disposition of a drug depends on its properties: drugs that pass through the lung are absorbed extremely rapidly into systemic circulation while others remain in the lung.  The presentation will provide an overview of the Technosphere powder technology and its applications.

Simplified drug delivery by inhalation, formulation, and device

244th National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.