A hybrid nanoparticle has been prepared that incorporates a solid lipid nanoparticle (SLN) core in a polyanionic capsule formed of crosslinked lanthanide 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate-complexes, [LnDOTA]-, where Ln = La, Eu, and Gd. The SLN core consists of emulsifying wax (EW) with the surfactant cetyltrimethylammonium (CTA) forming a cationic lipid boundary layer. Fluorescence and NMR data verify the formation of a stable capsule. Relaxivity measurements show the construct to have a higher relaxivity than monomolecular GdDOTA. The uptake of substituents in the lipid core for secondary imaging modalitites will be described.

Hybrid agent for magnetic resonance imaging with a GdDOTA capsule and a lipid core

244th National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.