We will report on the synthesis of targeted polyester nanosponges that are functionalized with radiation induced targeting units towards lung cancer. The supramolecular architecture of the nanosponge allows for the adjustment in the crosslinking density and we will present tailored release profiles that can be controlled through slight iterations of the nanoparticle structures. The tailored particles were loaded with paclitaxel and camptothecin and we will report the recent combination studies in mouse models of lung cancer. The emphasis in the presentation is set on the synthesis, adjustment of linear release profiles and the response in in vivo studies.

Targeted nanosponges: Tailored drug release influenced by crosslinking density of supramolecular architecture and in vivo efficacy in lung cancer

244th National Meeting (2012)

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