Non-steroidal anti-inflammatory drugs (NSAIDs) are used frequently to treat symptoms of pain and inflammation.  Although NSAIDs are effective in treatment of these symptoms, they can be responsible for serious side effects, in particular, gastrointestinal ulceration.  Second generation NSAIDs overcome these side effects, but chronic use can lead to an increase in the risk of heart attack and stroke. HNO (nitroxyl) and NO (nitric oxide) donors have demonstrated cardioprotective effects, and thus adducts with NSAIDs may prove to be safer and more effective than NSAIDs alone. A small library of NO/HNO releasing derivatives of NSAIDs were synthesized for the treatment of pain, inflammation and cancer. These compounds were characterized in their effectiveness as HNO/NO donors. The mechanism of decomposition and NO/HNO release were compared to the parent donors. Analysis showed that our prodrugs were releasing NO and HNO more effectively than their ionic precusors.

Synthesis and characterization of nitrogen oxide adducts with nonsteroidal anti-inflammatory drugs

244th National Meeting (2012)

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