Hydroxyl 1,2-diphenylpyridineethanamine analogs are disclosed as potent cholesterol ester transfer protein (CETP) inhibitors. SAR for the B-ring, Y position and for the amine substitution will be described leading to the discovery of the lead analog in this series (1  ) which demonstrated robust efficacy in CETP/apo-B-100 dual transgenic mice. Compound 1  did not produce blood pressure effects in telemetry rats at 30 mpk.

Hydroxyl 1,2-diphenylethanamine analogs as potent cholesterol ester transfer protein inhibitors

244th National Meeting (2012)

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