Previous results demonstrated that bis-1H-benzimidazoles represent promising leads as novel drug candidates against Plasmodium falciparum (Biorg Med Chem 2011, 19, 7493-7500).  Whereas some of the reported derivatives are characterized by high selectivity indexes against the parasite, a major drawback is their poor hydrophilicity thus precluding further in vivo studies. We now describe the design, preparation, and in vitro evaluation of novel analogs with improved solubility in water.

Novel bisbenzimidazoles with improved antiplasmodial activities

244th National Meeting (2012)

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