Kumiai first examined fungicidal triaryl-4-pyridones as tubulin inhibitors in 1987. Sumitomo disclosed diaryl pyridazines as tubulin-inhibiting fungicides in 2005. At DuPont we have examined both di- and tri-aryl pyridazines, as well as the related di-aryl-4-pyridones as tubulin-inhibiting fungicides. We will present the synthesis and structure activity relationships of the di- and tri-aryl-substituted pyridazines and the diaryl-4-pyridones, as well as their fungicidal evaluation.

Synthesis and biological activity of di- and tri-aryl pyridazines as broad spectrum fungicides

244th National Meeting (2012)

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