Inflammatory reactions are the basis of some of the most significant and common pathologies of modern society such as atherosclerosis, psoriaris, multiple sclerosis, etc. Accordingly, there is a significant and growing need to develop anti-inflammatory therapies while avoiding side effects (i.e target active principles to inflamed locations and to activated inflammatory cells, avoiding their action on non-inflammatory or non activated inflammatory cells). The objective of this study is to synthesize G0, G1 and G2 poly(L-lysine) sulfated dendrons that bind EGF-like growth factor. Moreover, the sulfated dendrons possess a catechol group at their focal point for subsequent attachment to other macromolecules using boronic acid chemistry. The presentation will focus on the development of these new structures, their detailed synthetic routes, and characterization.

Design of sulftated lysine-dendrons as scaffolds for fighting inflammation

244th National Meeting (2012)

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