Enantioselective ICD analysis of amino alcohols has been accomplished using two conformationally flexible dialdehyde probes that utilize distinctly different chiral induction mechanisms.  The chirality of the amino alcohol substrate is imprinted on the stereodynamic receptors upon [1+2] condensation, which ultimately generates a strong chiroptical response.  The distinct CD effects of the diimines obtained can be used for enantioselective sensing and enantiomeric excess determination of a wide range of substrates. 

Enantioselective sensing of chiral amino alcohols with stereodynamic dialdehyde probes

244th National Meeting (2012)

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