Amphiphilic polymeric materials are composed with hydrophilic portions and hydrophobic chains, and easily form micelles in aqueous solution via self-assembling. The core of micelles provides a hydrophobic micro-environment for storage of water-insoluble molecules. Consequently, amphiphilic polymers as nanocarriers for drug or bioactive compound delivery have received much attraction in recent studies.Hyaluronic acid (HA) is a naturally occurring polysaccharide found in living organisms. It could control cell permeability and regulate cell adhesion, migration, proliferation and differentiation. These unique physiological functions of HA reveal its potential use for clinical purpose. Herein, A novel comb-like amphiphilic copolymer, HA-g-PCL, was reported. The structure of the comb-like HA-g-PCL copolymer was identified by 1H-NMR and FT-IR. The HA-g-PCL copolymer self-assembles to form micelles at a concentration of around 1.6�10-3 mg/mL. The diameter of the HA-g-PCL micelles measured by DLS varied from 190 to 240 nm. The micelles were also observed using TEM with sizes ranging from 160 to 250 nm. This comb-like HA-g-PCL copolymer could be utilized as a nanocarrier for drug or bioactive molecule delivery.

Development of a novel HA-based micelle material as a potent nanocarrier for targeting delivery

244th National Meeting (2012)

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