Hydrogels that consist of boronic acid monomers combined with thermoresponsive monomers to amplify the solubility response were recently established to undergo sugar induced swelling. Well-defined glucose responsive polymers are favourable for the development of glucose responsive drug carriers but also as soluble sensors.The aim of this work was the development of a simple synthetic procedure for preparing boronic acid containing polymers. Additionally, the copolymerization of solvatochromic dyes was aimed to lead to glucose sensors by translation of the polymer phase transition, which is accompanied by a change in the polarity around the polymer chain, into an optical or fluorescent response by the solvatochromic dyes. Such sensing mechanisms are not yet known for glucose-responsive polymers or for molecule-responsive polymers in general.

From boronic acid containing polymers to sugar sensors

244th National Meeting (2012)

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