N,N,N-trimethyl chitosan (TMC) was synthesized through the N-methylation of chitosan (CHT) and characterized by FTIR and 1H NMR spectroscopy. Polyelectrolyte complexes (PECs) based on TMC and heparin (HP) were prepared at different pHs (5, 8, 10 and 12) and characterized through FTIR spectroscopy, DSC / TGA curves and WAXS pro?les. It was veri?ed that the higher the pH of feed solution used for the PEC formation the higher is the thermal stability of PECs. Under basic conditions, the complexation between TMC and HP was more effective. Alterations on WAXS pro?les of PECs relative to the precursor (TMC) were clearly observed. In addition, WAXS pro?les show that the TMC/HP PEC crystallinity depends on the pH used for the complexation (see Figure 1).   The release profiles of HP from TMC/HP PEC are quite different as the pH for PEC formation is changed (see Figure 2).   Data show that PEC of TMC/HP formed at pH 8 is a promising material for uses in oral site-specific HP release systems.

Polyelectrolyte complexes of N,N,N-trimethyl chitosan/heparin: Methodology of preparation, evaluation of controlled release of heparin, and of other important properties

244th National Meeting (2012)

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