Soybean oil-based polymers were prepared by the ring-opening polymerization of epoxidized soybean oil with Lewis acid catalyst. The formed polymers (PESO) could be converted into hydrogels (HPESO) through hydrolysis. Characterization and viscoelastic properties of this soy hyrdrogels and application in control release anticancer drugs were investigated. The HPESO hydrogels exhibited viscoelastic solid or gel behavior above 2% (wt. %) concentration at room temperature and viscous liquid behavior at 55 �C. The thermal assembly, disassembly, and reassembly function of the HPESO hydrogel was completely reversible. The function and behavior of the HPESO hydrogel suggest that this biomaterial is suitable for applications in drug delivery and scaffolds of bioengineering. Meanwhile the HPESO hydrogels were evaluated loading and release water-soluble anticancer drug doxorubin (Dox).The results show that this new system may offer great potential to deliver Dox effectively for the treatment of MDR breast cancer.

Study of soybean oil-based polymers for controlled release anticancer drugs

244th National Meeting (2012)

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