Verbesina, an annual-to-herbaceous perennial from the Americas, represents the largest genus of the Heliantheae tribe in the Asteraceae family. Several Verbesina species are used to treat a variety of disorders, including urinary and gastrointestinal tract complaints. Importantly, many Heliantheae compounds also possess antiparasitic, antifungal, and antioxidant activity. The most common secondary metabolites found in Verbesina genus are the eudesmanes. In addition, germacrenes, flavonoids, guanidine alkaloids, acetylenic compounds, and several other terpenes with a great variety of hydrocarbon skeletons have been isolated. The active chloroformic extract obtained from the aerial parts of Verbesina negrensis was subjected to a bioassay-guided fractionation using disk-diffusion assays. This approach allowed the isolation and identification of the novel active compound 6�-cinnamoyloxy-1�-hydroxy-10a-metoxy-3-oxo-germacra-4,5Z-ene (1) . Subsequent MIC tests revealed growth inhibition (64 �g/mL) against both Enterococcus faecalis (ATCC 29212) and Staphylococcus aureus (ATCC 25923) for Verbesina fractions containing 1 . These results constitute the first report of active compounds from Verbesina negrensis.

New antibacterial germacrene from <i>Verbesina negrensis </i>Steyerm

244th National Meeting (2012)

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New antibacterial germacrene from Verbesina negrensis Steyerm